Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.

@article{Silakowski2001NovelFI,
  title={Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.},
  author={Barbara Silakowski and Gabriele Nordsiek and Brigitte Kunze and Helmut Bloecker and Rolf M{\"u}ller},
  journal={Chemistry & biology},
  year={2001},
  volume={8 1},
  pages={59-69}
}
BACKGROUND Myxobacteria have been well established as a potent source for natural products with biological activity. They produce a considerable variety of compounds which represent typical polyketide structures with incorporated amino acids (e.g. the epothilons, the myxothiazols and the myxalamids). Several of these secondary metabolites are effective inhibitors of the electron transport via the respiratory chain and have been widely used. Molecular cloning and characterization of the genes… CONTINUE READING