Novel export control of a Legionella Dot/Icm substrate is mediated by dual, independent signal sequences.


The Legionella pneumophila Dot/Icm T4SS injects ∼ 300 protein effector proteins into host cells. Dot/Icm substrates have been proposed to contain a carboxy-terminal signal sequence that is necessary and sufficient for export, although both traits have been demonstrated for only a small fraction of these proteins. In this study, we discovered that export of… (More)
DOI: 10.1111/mmi.12928



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