Novel excitatory Conus peptides define a new conotoxin superfamily.

@article{Jimenez2003NovelEC,
  title={Novel excitatory Conus peptides define a new conotoxin superfamily.},
  author={Elsie C. Jimenez and Reshma P Shetty and Marcelina B Lirazan and Jean Rivier and Craig G. Walker and Fe C. Abogadie and Doju Yoshikami and Lourdes J. Cruz and Baldomero M Olivera},
  journal={Journal of neurochemistry},
  year={2003},
  volume={85 3},
  pages={610-21}
}
A new class of Conus peptides, the I-superfamily of conotoxins, has been characterized using biochemical, electrophysiological and molecular genetic methods. Peptides in this superfamily have a novel pattern of eight Cys residues. Five peptides that elicited excitatory symptomatology, r11a, r11b, r11c, r11d and r11e, were purified from Conus radiatus venom; four were tested on amphibian peripheral axons and shown to elicit repetitive action potentials, consistent with being members of the… CONTINUE READING

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