Novel events in the molecular regulation of muscle mass in critically ill patients.

@article{Constantin2011NovelEI,
  title={Novel events in the molecular regulation of muscle mass in critically ill patients.},
  author={Despina Constantin and Justine McCullough and Ravi P Mahajan and Paul L Greenhaff},
  journal={The Journal of physiology},
  year={2011},
  volume={589 Pt 15},
  pages={3883-95}
}
Critically ill patients experience marked skeletal muscle atrophy, but the molecular mechanisms responsible for this are largely unresolved. Therefore, we investigated key genes and proteins, identified from cell and animal studies to control protein synthesis and breakdown, in vastus lateralis biopsy samples obtained from 10 patients and 10 age- and sex-matched healthy controls. Muscle cytokines IL-6 and TNF-α mRNA were higher in patients than in controls(6.5-fold; P < 0.001 and 2-fold; P < 0… CONTINUE READING
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