Novel epoxyfuranoid lignans and antitubercular constituents from the leaves of Beilschmiedia tsangii.

@article{Chen2007NovelEL,
  title={Novel epoxyfuranoid lignans and antitubercular constituents from the leaves of Beilschmiedia tsangii.},
  author={J J Chen and En-Tzu Chou and Chien-Fang Peng and Ih-Sheng Chen and Sheng-Zehn Yang and Hung-Yi Huang},
  journal={Planta medica},
  year={2007},
  volume={73 6},
  pages={567-71}
}
Three new epoxyfuranoid lignans, 4alpha,5alpha-epoxybeilschmin A (1), 4alpha,5alpha-epoxybeilschmin B (2), and beilschmin D (3), together with nine known compounds have been isolated from the leaves of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (4) and beilschmin B (5) exhibited potent antitubercular activities (MICs = 2.5 and 7.5 microg/mL, respectively) against Mycobacterium tuberculosis 90 - 221387… CONTINUE READING