Novel epididymal protease inhibitors with Kazal or WAP family domain.

@article{Jalkanen2006NovelEP,
  title={Novel epididymal protease inhibitors with Kazal or WAP family domain.},
  author={Jenni Jalkanen and Mika Kotim{\"a}ki and I lpo Huhtaniemi and Matti Poutanen},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={349 1},
  pages={245-54}
}
The epididymal maturation of spermatozoa is regulated by changes in the luminal ion concentration and the processing of the sperm surface membrane by several glycosidases and proteases. In the present study, we identified five novel protease inhibitors that are highly expressed in the mouse epididymis. Four of the proteins were found to belong to the Kazal protease inhibitor family and were named SPINK8, SPINK10, SPINK11, and SPINK12, whereas one of the proteins, WFDC10, contained the WAP four… CONTINUE READING