Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.

  title={Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.},
  author={Philipp Henneke and Osamu Takeuchi and Jos A. G. van Strijp and H K Guttormsen and Jason Anthony Smith and Andra Beate Schromm and Terje Espevik and Shizuo Akira and Victor Nizet and Dennis L Kasper and Douglas T Golenbock},
  journal={Journal of immunology},
  volume={167 12},
Group B streptococcus (GBS) imposes a major health threat to newborn infants. Little is known about the molecular basis of GBS-induced sepsis. Both heat-inactivated whole GBS bacteria and a heat-labile soluble factor released by GBS during growth (GBS-F) induce nuclear translocation of NF-kappaB, the secretion of TNF-alpha, and the formation of NO in mouse macrophages. Macrophages from mice with a targeted disruption of MyD88 failed to secrete TNF-alpha in response to both heat-inactivated… CONTINUE READING
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