Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

@article{Miranda2014NovelET,
  title={Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.},
  author={Daniela P J Miranda and Rita Capela and In{\^e}s S Albuquerque and Patr{\'i}cia Andrade Meireles and Isa Paiva and Fatima Nogueira and Richard K. Amewu and Jiri Gut and Philip J. Rosenthal and Rudi Oliveira and Maria M Mota and Rui Moreira and Francesc Mart{\'i} and Miguel Prud{\^e}ncio and Paul M O'neill and Francisca Lopes},
  journal={ACS medicinal chemistry letters},
  year={2014},
  volume={5 2},
  pages={108-12}
}
In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors, a series of hybrid compounds combining either a 1,2,4-trioxane or 1,2,4,5-tetraoxane and 8-aminoquinoline moieties were synthesized and screened for their antimalarial activity. These hybrid compounds showed high potency against both exoerythrocytic and erythrocytic forms of malaria parasites, comparable to… CONTINUE READING

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