Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

  title={Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.},
  author={Daniela P J Miranda and Rita Capela and In{\^e}s S Albuquerque and Patr{\'i}cia Andrade Meireles and Isa Paiva and Fatima Nogueira and Richard K. Amewu and Jiri Gut and Philip J. Rosenthal and Rudi Oliveira and Maria M Mota and Rui Moreira and Francesc Mart{\'i} and Miguel Prud{\^e}ncio and Paul Michael O'neill and Francisca Lopes},
  journal={ACS medicinal chemistry letters},
  volume={5 2},
In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors, a series of hybrid compounds combining either a 1,2,4-trioxane or 1,2,4,5-tetraoxane and 8-aminoquinoline moieties were synthesized and screened for their antimalarial activity. These hybrid compounds showed high potency against both exoerythrocytic and erythrocytic forms of malaria parasites, comparable to… CONTINUE READING

From This Paper

Topics from this paper.


Publications referenced by this paper.

Design and evaluation of primaquine - artemisinin hybrids as a multistage antimalarial strategy

  • P. M. O’Neill, R. K. Amewu, +16 authors S. A. Ward
  • Antimicrob . Agents Chemother .
  • 2011

Similar Papers

Loading similar papers…