Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.


In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors, a series of hybrid compounds combining either a 1,2,4-trioxane or 1,2,4,5-tetraoxane and 8-aminoquinoline moieties were synthesized and screened for their antimalarial… (More)
DOI: 10.1021/ml4002985


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