Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.

@article{Kim2016NovelEO,
  title={Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.},
  author={H. Kim and G. J. Kang and E. J. Kim and M. K. Park and Hyun Jung Byun and S. Nam and H. Lee and C. Lee},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1862 9},
  pages={
          1533-43
        }
}
  • H. Kim, G. J. Kang, +5 authors C. Lee
  • Published 2016
  • Biology, Medicine
  • Biochimica et biophysica acta
  • Sphingosylphosphorylcholine (SPC) participates in several cellular processes including metastasis. SPC induces keratin reorganization and regulates the viscoelasticity of metastatic cancer cells including PANC-1 cancer cells leading to enhanced migration and invasion. The role of SPC and the relevant mechanism in invasion of breast cell are as yet unknown. SPC dose-dependently induces invasion of breast cancer cells or breast immortalized cells. Reverse transcription polymerase chain reaction… CONTINUE READING
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