Novel effects of insulin secretagogues on capacitation of insulin release and survival of cultured pancreatic islets.

@article{MacDonald1990NovelEO,
  title={Novel effects of insulin secretagogues on capacitation of insulin release and survival of cultured pancreatic islets.},
  author={Michael J. MacDonald and Leonard A. Fahien and Douglas Mckenzie and Susan M. Moran},
  journal={The American journal of physiology},
  year={1990},
  volume={259 4 Pt 1},
  pages={
          E548-54
        }
}
Agents that stimulate insulin release from fresh pancreatic islets were tested for their ability to capacitate pancreatic islets to secrete insulin and to support beta-cell survival in tissue culture. Capacitation was defined as the ability to release insulin after 24 h in culture in the presence of an insulinotropic concentration of a secretagogue. Viable islets that lose glucose-induced insulin release gradually regain it during culture for 24 h in 20 mM glucose. Survival was defined as the… CONTINUE READING
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