Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.

@article{Sterling2002NovelDI,
  title={Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.},
  author={Jeffrey E. Sterling and Yaacov Herzig and Tamar Goren and Nina Finkelstein and David Lerner and Willy Goldenberg and Istvan Miskolczi and S{\'a}ndor Moln{\'a}r and Ferenc Rantal and Tivadar Tamas and Gyorgy Toth and Adela Zagyva and Andras Zekany and John P. M. Finberg and Gila Lavian and Aviva Gross and Rachel Friedman and Michal Razin and Wei Huang and Boris Krais and Michael Chorev and Moussa B. H. Youdim and Marta Weinstock},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 24},
  pages={5260-79}
}
Carbamate derivatives of N-propargylaminoindans (Series I) and N-propargylphenethylamines (Series II) were synthesized via multistep procedures from the corresponding hydroxy precursors. The respective rasagiline- and selegiline-related series were designed to combine inhibitory activities of both acetylcholine esterase (AChE) and monoamine oxidase (MAO) by virtue of their carbamoyl and propargylamine pharmacophores. Each compound was tested for these activities in vitro in order to find… CONTINUE READING

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