Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts.

@article{Kanhoush2010NovelDI,
  title={Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts.},
  author={Rasha Kanhoush and Brent Beenders and Caroline Perrin and Jacques Moreau and Michel Bellini and M Penrad-Mobayed},
  journal={Nucleus},
  year={2010},
  volume={1 1},
  pages={109-22}
}
The heterogenous nuclear ribonucleoprotein G (hnRNP G) controls the alternative splicing of several pre-mRNas. While hnRNP G displays an amino terminal RNA recognition motif (RRM), we find that this motif is paradoxically not implicated in the recruitment of hnRNP G to nascent transcripts in amphibian oocytes. In fact, a deletion analysis revealed that targeting of hnRNP G to active transcription units depends on another domain, centrally positioned, and consisting of residues 186-236. We show… CONTINUE READING
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