Novel domains and orthologues of eukaryotic transcription elongation factors.

@article{Ponting2002NovelDA,
  title={Novel domains and orthologues of eukaryotic transcription elongation factors.},
  author={Chris Paul Ponting},
  journal={Nucleic acids research},
  year={2002},
  volume={30 17},
  pages={3643-52}
}
The passage of RNA polymerase II across eukaryotic genes is impeded by the nucleosome, an octamer of histones H2A, H2B, H3 and H4 dimers. More than a dozen factors in the yeast Saccharomyces cerevisiae are known to facilitate transcription elongation through chromatin. In order to better understand the evolution and function of these factors, their sequences have been compared with known protein, EST and DNA sequences. Elongator subcomplex components Elp4p and Elp6p are shown to be homologues… CONTINUE READING

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