Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.

@article{Marcheselli2003NovelDI,
  title={Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.},
  author={Victor L. Marcheselli and Song Hong and Walter J. Lukiw and Xiao Hua Tian and Karsten Gronert and Alberto E. Musto and Mattie N Hardy and Juan Mill{\'e} Gim{\'e}nez and Nan Chiang and Charles Nicholas Serhan and Nicolas G Bazan},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 44},
  pages={
          43807-17
        }
}
Ischemic stroke triggers lipid peroxidation and neuronal injury. Docosahexaenoic acid released from membrane phospholipids during brain ischemia is a major source of lipid peroxides. Leukocyte infiltration and pro-inflammatory gene expression also contribute to stroke damage. In this study using lipidomic analysis, we have identified stereospecific messengers from docosahexaenoate-oxygenation pathways in a mouse stroke model. Aspirin, widely used to prevent cerebrovascular disease, activates an… CONTINUE READING
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