Novel disulphide esters of carbothioic acid as potent, non-detergent spermicides with low toxicity to Lactobacillus and HeLa cells in vitro.

Abstract

BACKGROUND The design, synthesis, characterization and evaluation of a novel series of non-detergent spermicides has led to the discovery of two unique molecules (DSE-36 and DSE-37) that were approximately 25 times more potent spermicides than nonoxynol-9 (N-9). METHODS Normal human spermatozoa were used to assess the spermicidal activity (Sander-Cramer… (More)

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@article{Jain2007NovelDE, title={Novel disulphide esters of carbothioic acid as potent, non-detergent spermicides with low toxicity to Lactobacillus and HeLa cells in vitro.}, author={R. K. Jain and Jagdamba Prasad Maikhuri and Singarapu Kiran Kumar and Vishnu Lal Sharma and A. K. Dwivedi and K.. Mitra and Virendra Kumar Bajpai and G. Gupta}, journal={Human reproduction}, year={2007}, volume={22 3}, pages={708-16} }