Novel disease targets and management approaches for diffuse large B-cell lymphoma.

@article{Wilson2010NovelDT,
  title={Novel disease targets and management approaches for diffuse large B-cell lymphoma.},
  author={Wyndham H. Wilson and Francisco J Hernandez-Ilizaliturri and Kieron Dunleavy and Richard F Little and Owen A O'connor},
  journal={Leukemia & lymphoma},
  year={2010},
  volume={51 Suppl 1},
  pages={
          1-10
        }
}
Diffuse large B-cell lymphoma (DLBCL) responds well to treatment with CHOP and the R-CHOP regimen, but a subset of patients still fail to achieve complete or durable responses. Recent advances in gene expression profiling have led to the identification of three different subtypes of DLBCL, and confirmed that patients with the activated B-cell (ABC) disease subtype are less likely to respond well to CHOP-based regimens than those with germinal centre B-cell-type (GCB) disease. This discovery… CONTINUE READING
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