Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium.

@article{Ventura1992NovelDD,
  title={Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium.},
  author={Carlo Ventura and Robert Miller and Hamilton Parker Wolf and Norbert Beier and Rochus Jonas and Michael Klockow and Inge Lues and O Hano and Harold Albert Spurgeon and Edward G. Lakatta},
  journal={Circulation research},
  year={1992},
  volume={70 6},
  pages={1081-90}
}
The inotropic state of the myocardium can be enhanced via an increase in cell Ca2+ loading or in myofilament responsiveness to Ca2+. Although different pharmacological agents combine these properties, no presently available drug acts predominantly as a myofilament sensitizer in situ. We have investigated the effects and the mechanism of action of novel diazinone derivatives, EMD 54622, EMD 53998, and EMD 54650 (developed by E. Merck, Darmstadt), on guinea pig myocardial preparations. Force- and… CONTINUE READING

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