Novel cytotoxic polyoxygenated steroids from an Okinawan sponge Dysidea sp.

@article{Govindam2012NovelCP,
  title={Novel cytotoxic polyoxygenated steroids from an Okinawan sponge Dysidea sp.},
  author={Sudhakar V S Govindam and Bong-Keun Choi and Yukio Yoshioka and Akihiko Kanamoto and Takeshi Fujiwara and Tetsuji Okamoto and Makoto Ojika},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2012},
  volume={76 5},
  pages={999-1002}
}
A library of extracts established from hundreds of marine organisms was screened by a cytotoxicity test. The active organic extract of an Okinawan marine sponge of the genus Dysidea was subjected to bioassay-guided fractionation to give three new polyoxygenated steroids dysideasterols F-H (1-3), together with two known related compounds (4 and 5). Their structures were confirmed by NMR and mass spectroscopic analyses. A characteristic structural feature of 2, 4 and 5 is an allylic epoxide… CONTINUE READING