Novel cytotoxic peptides from the tropical marine cyanobacteriumHormothamnion enteromorphoides 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material

@article{Gerwick2005NovelCP,
  title={Novel cytotoxic peptides from the tropical marine cyanobacteriumHormothamnion enteromorphoides 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material},
  author={W. Gerwick and C. Mrozek and M. Moghaddam and S. K. Agarwal},
  journal={Experientia},
  year={2005},
  volume={45},
  pages={115-121}
}
  • W. Gerwick, C. Mrozek, +1 author S. K. Agarwal
  • Published 2005
  • Biology, Medicine
  • Experientia
  • A Caribbean cyanobacterium,Hormothamnion enteromorphoides, was found to produce a complex mixture of ichthyotoxic peptides, perhaps explaining the apparent absence of predation upon these potentially palatable life forms. Bioassay-guided fractionation was used to isolate these toxic and antimicrobial natural products, and a variety of techniques including HR FAB mass spectrometry, 2D-NMR, traditional hydrolysis-amino acid analysis, and several chemical reactions were used to define the basic… CONTINUE READING
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