Novel cytotoxic annonaceous acetogenins from Annona muricata.

  title={Novel cytotoxic annonaceous acetogenins from Annona muricata.},
  author={Fang‐Rong Chang and Y. C. Wu},
  journal={Journal of natural products},
  volume={64 7},
  • F. Chang, Y. C. Wu
  • Published 7 July 2001
  • Biology, Chemistry
  • Journal of natural products
Seven new annonaceous acetogenins, muricins A-G (1-7), as well as five known compounds, a mixture of muricatetrocin A (8) and muricatetrocin B (9), longifolicin (10), corossolin (11), and corossolone (12), were isolated from the seeds of Annona muricata. The structures of all isolates were elucidated and characterized by spectral and chemical methods. These acetogenins showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines Hep G(2) and 2,2,15. 
Four cytotoxic annonaceous acetogenins from the seeds of Annona squamosa
Four new annonaceous acetogenins (ACGs), squamocin-I (1), II (2) and III (3) and squamoxinone-D (4), together with seven known ACGs (5–11), were isolated from the seeds of Annona squamosa. The
Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa.
Three new bistetrahydrofuran annonaceous acetogenins (1-3) were isolated from a 95% EtOH extract of Annona squamosa seeds and exhibited significant cytotoxic activity in vitro against five human tumor cell lines.
Caribbean Soursop (Annona Muricata) Varieties II: AnnonaceousAcetogenin Properties
This study evaluated extracts of the leaf, fruit, seed, bark and roots of two types of fruit, which have high fibre, or fibreless fruit and are cultivated locally, and found more flavonoid type compounds in the leaf extracts and fewer, if any, acetogenins.
Acetogenins from Annonaceae.
The aim of the present contribution is to summarize chemical and biological reports published since 1997 on annonaceous acetogenins and synthetic acetogenin mimics to summarize their cytotoxicity for cancer cell lines, neurotoxicity, pesticidal effects, and miscellaneous activities.
Historic perspectives on Annonaceous acetogenins from the chemical bench to preclinical trials.
The purpose of this review is to give an account of recent studies on this class of compounds and their analogues, which will aid not only in clarifying how the Annonaceous acetogenins act but also in establishing principles for the further development of thisclass of compounds.