Novel cytotoxic, alkylated hydroquinones from Lannea welwitschii.

@article{Groweiss1997NovelCA,
  title={Novel cytotoxic, alkylated hydroquinones from Lannea welwitschii.},
  author={Amiram Groweiss and John H. Cardellina and Lewis K. Pannell and Duangchan Uyakul and Yoel Kashman and Michael R. Boyd},
  journal={Journal of natural products},
  year={1997},
  volume={60 2},
  pages={
          116-21
        }
}
Two novel natural products, lanneaquinol (1) and 2'(R)-hydroxylanneaquinol (2), were isolated from the organic extract of the plant Lannea welwitschii (Hiern) Engl. Their structures were solved by spectroanalytical methods and confirmed by comparison to synthetic models. The absolute configuration of 2 was determined by the modified Mosher method. Both compounds exhibited modest cytotoxicity against the NCI panel of 60 human tumor cell lines. The structures of two isomeric 4,5-dihydroxy-5-alkyl… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Similar Papers

Loading similar papers…