Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells

@article{Pardo2001NovelCT,
  title={Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells},
  author={Olivier E. Pardo and Alexandre Arcaro and Giovanni Luca Salerno and Teresa D. Tetley and Taras Valovka and Ivan Gout and Michael J. Seckl},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={7658-7667}
}
Here, we show that fibroblast growth factor-2 (FGF-2) induces proliferation of H-510 and H-69 small cell lung cancer (SCLC) cells. However, the optimal response to FGF-2 was obtained at 10-fold lower concentrations in H-510 cells. This correlated with the selective activation of the mitogen-activated protein kinase kinase (MEK) pathway in H-510, but not H-69 cells. Moreover, inhibition of MEK with PD098059 blocked FGF-2-induced proliferation in H-510 cells only. Similarly, ribosomal protein S6… CONTINUE READING
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