Novel cross-reactive anti-idiotype antibodies with properties close to the human intravenous immunoglobulin (IVIg).

@article{Macas1999NovelCA,
  title={Novel cross-reactive anti-idiotype antibodies with properties close to the human intravenous immunoglobulin (IVIg).},
  author={Alfonso Guti{\'e}rrez Mac{\'i}as and S. Enrique Arce and Javier Nieto Le{\'o}n and Geraudis Mustelier and G. Bombino and Alberto Domarco and Rafael Hinojosa P{\'e}rez and A. von der Lage},
  journal={Hybridoma},
  year={1999},
  volume={18 3},
  pages={
          263-72
        }
}
The most important link between the immune network theory and clinically useful therapies so far is the use of human intravenous immunoglobulin (IVIg) in the treatment of autoimmune diseases. Although still controversial, one of the main mechanisms that has been postulated for the in vivo effects of IVIg, is the selection of immune repertoires through idiotypic interactions. We describe here anti-idiotype IgG monoclonal antibodies (MAbs), which were obtained by immunization of syngeneic mice… CONTINUE READING
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