Novel consensus DNA‐binding sequence for BRCA1 protein complexes

@article{Cable2003NovelCD,
  title={Novel consensus DNA‐binding sequence for BRCA1 protein complexes},
  author={P LouAnn Cable and Cindy A. Wilson and Frank J. Calzone and Frank J. Rauscher and Ralph Scully and David M Livingston and LePing Li and Courtney B. Blackwell and P. Andrew Futreal and Cynthia A. Afshari},
  journal={Molecular Carcinogenesis},
  year={2003},
  volume={38}
}
Increasing evidence continues to emerge supporting the early hypothesis that BRCA1 might be involved in transcriptional processes. BRCA1 physically associates with more than 15 different proteins involved in transcription and is paradoxically involved in both transcriptional activation and repression. However, the underlying mechanism by which BRCA1 affects the gene expression of various genes remains speculative. In this study, we provide evidence that BRCA1 protein complexes interact with… 
Methylation of the Tumor Suppressor Protein, BRCA1, Influences Its Transcriptional Cofactor Function
TLDR
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TLDR
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TLDR
A critical role is revealed for BRCA1 and, to a smaller degree, PALB2 in transcriptional responsiveness to NF‐κB, a crucial mediator of growth and inflammatory response during development and cancer, and an important role is uncovered for these breast cancer proteins in the regulation of diverse growth regulatory pathways.
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
TLDR
The R1699Q variant of BRCA1, a potentially moderate-risk variant, is studied and it is found that it does not impair DNA damage repair but abrogates the repression of microRNA-155 (miR-155), a bona fide oncomir, and this finding suggests that miR- 155 is a potential therapeutic target for BRCa1-deficient tumors.
BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27Kip1
TLDR
RNA and protein analysis as well as immunohistochemistry showed that expression of FOXA1 correlated with the expression of the estrogen receptor in a panel of breast cancer cell lines and tissues and it was shown that FoxA1 could activate the p27Kip1 promoter alone and in conjunction with BRCA1.
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