Novel compounds for the treatment of HIV type-1 infection.

  title={Novel compounds for the treatment of HIV type-1 infection.},
  author={Hans J{\"u}rgen Stellbrink},
  journal={Antiviral chemistry & chemotherapy},
  volume={19 5},
Despite the recent licensure of several new antiretroviral compounds, there is still a need to develop additional agents. Problems with antiviral activity, tolerability, ease of administration, extent of cross-resistance and pharmacokinetic as well as pharmacodynamic interactions still represent important obstacles to life-long control of HIV type-1 replication by highly active antiretroviral therapy. Several compounds stem from the same classes as currently available drugs: apricitabine and… CONTINUE READING