Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.

Abstract

A series of combretastatin A-4 (CA-4) analogues were synthesized, and their cytotoxic effects against murine Colon 26 adenocarcinoma and inhibitory activity on tubulin polymerization were evaluated. Since CA-4 has limited aqueous solubility, the target compounds were designed to improve solubility by introduction of a nitrogen-containing group. Among the… (More)

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@article{Ohsumi1998NovelCA, title={Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.}, author={Koji Ohsumi and Reiko Nakagawa and Y Fukuda and Takanori Hatanaka and Yoshiko Morinaga and Yukio Nihei and Kenji Ohishi and Yasushi Suga and Y Akiyama and Takao Tsuji}, journal={Journal of medicinal chemistry}, year={1998}, volume={41 16}, pages={3022-32} }