Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers

@article{VcseySemjn2002NovelCC,
  title={Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers},
  author={Beatrix V{\'e}csey-Semj{\'e}n and K. -F. Becker and Alexandra Sinski and Elizabeth Blennow and Ilja Vietor and Kurt Zatloukal and Hartmut Beug and Ernst Wagner and Lukas A. Huber},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={4646-4662}
}
A major obstacle to obtaining more detailed insights into the diversity of phenotypic and molecular changes occurring in colon cancer cells is the lack of low-passage colon cancer cell lines, which would still closely reflect the phenotype of the colon cancer cells in vivo. Here, we characterize eight novel, low passage number human colon carcinoma cell lines, originating from colorectal cancers extensively characterized in the clinics. All cell lines closely resemble the original tumors with… CONTINUE READING