Novel class of bivalent glutathione S-transferase inhibitors.

  title={Novel class of bivalent glutathione S-transferase inhibitors.},
  author={Robert P. Lyon and John J Hill and William M Atkins},
  volume={42 35},
Exploiting the principle of bivalent binding, we have designed symmetrical, bifunctional inhibitors to simultaneously occupy both active sites of cytosolic glutathione S-transferase, with enhanced specificity for the P1-1 isoform. We have prepared two series of compounds that differ in their binding domains-the first is a series of bis-glutathione conjugates, and the second is a series of compounds each possessing two equivalents of Uniblue A, an analogue of Cibacron Blue. For each series, a… CONTINUE READING

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