Novel chromosome 16 abnormality--der(16)del(16) (q13)t(16;21)(p11.2;q22)--associated with acute myeloid leukemia.

@article{Sharma1999NovelC1,
  title={Novel chromosome 16 abnormality--der(16)del(16) (q13)t(16;21)(p11.2;q22)--associated with acute myeloid leukemia.},
  author={P. Sharma and N. Watson and L. Robson and J. Gallo and A. Smith},
  journal={Cancer genetics and cytogenetics},
  year={1999},
  volume={113 1},
  pages={
          25-8
        }
}
  • P. Sharma, N. Watson, +2 authors A. Smith
  • Published 1999
  • Biology, Medicine
  • Cancer genetics and cytogenetics
    • Inversion of chromosome 16 is a common feature of acute myeloid leukemia (AML) M4, while t(16;21), although also associated with AML, appears to be a separate entity. We present a patient with myelodysplastic syndrome (MDS) who transformed to AML-M1. The karyotype was normal at diagnosis; at 15 months, hematological evidence of transformation was present, and repeat cytogenetics showed a novel rearrangement of one chromosome 16. Two breaks had occurred; one in the short arm at 16p11, with… CONTINUE READING
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