Novel cholesterol spermine conjugates provide efficient cellular delivery of plasmid DNA and small interfering RNA.

@article{Maslov2012NovelCS,
  title={Novel cholesterol spermine conjugates provide efficient cellular delivery of plasmid DNA and small interfering RNA.},
  author={Mikhail A Maslov and Tatyana O. Kabilova and Ivan A Petukhov and Nina G. Morozova and Galina A Serebrennikova and Valentine V Vlassov and Marina A. Zenkova},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={160 2},
  pages={182-93}
}
New polycationic lipids corresponding to the two different classes of amphiphiles ("head-tail" and "gemini") were designed and used as components of non-viral gene delivery systems. The hydrophobic domain of lipids is based on the cholesterol residue and the hydrophilic one--on the naturally occurring polyamine--spermine. Ester and carbamate linker groups… CONTINUE READING