Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor

Abstract

Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits inflammation in inflammatory disease models. Therefore, we anticipate that inhibition of Grx1 could be an anti… (More)
DOI: 10.1371/journal.pone.0187991

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@inproceedings{Miller2017NovelCC, title={Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor}, author={Olga Gorelenkova Miller and Kyle S Cole and Corey C Emerson and Dharmaraja Allimuthu and Marcin Golczak and Phoebe L. Stewart and Eranthie Weerapana and Drew J Adams and John J. Mieyal}, booktitle={PloS one}, year={2017} }