Novel chlorinated tropanes derived from the treatment of cocaine with sodium hypochlorite.

Abstract

Several novel chlorinated tropanes were produced when cocaine was treated with aqueous sodium hypochlorite. Two of these, 2'- and 3'-chlorobenzoyloxy-2-carbomethoxypseudotropine (that is, ortho- and meta-chlorococaine), were characterized by synthesis and gas chromatography/mass spectrometry. Four other new chlorinated tropanes (endo-6- and 7-chlorococaine, exo-6- or 7-chlorococaine and N-chlorobenzoylnorecgonine methyl ester) were also tentatively identified via their gas chromatography retention data and mass spectra. The results are of potential use in cocaine signature and comparative analysis.

Cite this paper

@article{Casale1995NovelCT, title={Novel chlorinated tropanes derived from the treatment of cocaine with sodium hypochlorite.}, author={John F. Casale and Jenna M. Moore and Deyna Cooper}, journal={Journal of forensic sciences}, year={1995}, volume={40 5}, pages={816-22} }