Novel chitosan-based hyaluronan hybrid polymer fibers as a scaffold in ligament tissue engineering.

@article{Funakoshi2005NovelCH,
  title={Novel chitosan-based hyaluronan hybrid polymer fibers as a scaffold in ligament tissue engineering.},
  author={Tadanao Funakoshi and Tokifumi Majima and Norimasa Iwasaki and Shintaro Yamane and Tatsuya Masuko and Akio Minami and Kazuo Harada and Hiroshi Tamura and Seiichi Tokura and Shin-Ichiro Nishimura},
  journal={Journal of biomedical materials research. Part A},
  year={2005},
  volume={74 3},
  pages={338-46}
}
To clarify the feasibility of using novel chitosan-based hyaluronan hybrid polymer fibers as a scaffold in ligament tissue engineering, their mechanical properties and ability to promote cellular adhesion, proliferation, and extracellular matrix production were studied in vitro. Chitosan fibers and chitosan-based 0.05% and 0.1% hyaluronan hybrid fibers were developed by the wet spinning method. Hyaluronan coating significantly increased mechanical properties, compared to the chitosan fibers… CONTINUE READING

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