Novel chicken CXC and CC chemokines.

@article{Sick2000NovelCC,
  title={Novel chicken CXC and CC chemokines.},
  author={C Sick and Kirsten Schneider and Peter Staeheli and K C Weining},
  journal={Cytokine},
  year={2000},
  volume={12 3},
  pages={181-6}
}
Upon stimulation with lipopolysaccharide (LPS) the chicken macrophage cell line HD-11 secretes factors with cytokine activity. To characterize these molecules, representational difference analysis with RNA of LPS-induced and uninduced HD-11 cells was performed. Two cDNA clones were isolated that code for polypeptides with structural features of chemokines. cDNA K60 codes for a novel CXC chemokine of 104 residues including a putative signal peptide of 20 amino acids at the N-terminus. It is 67… CONTINUE READING

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