Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

@article{Kumar2011NovelCD,
  title={Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.},
  author={Vineet Kumar and Sarvesh Kumar and Mohammad Hassan and Hailong Wu and Rajesh K. Thimmulappa and Amit Kumar and Sunil K. Sharma and Virinder Singh Parmar and Shyam Biswal and Sanjay V. Malhotra},
  journal={Journal of medicinal chemistry},
  year={2011},
  volume={54 12},
  pages={4147-59}
}
Nrf2-mediated activation of antioxidant response element is a central part of molecular mechanisms governing the protective function of phase II detoxification and antioxidant enzymes against carcinogenesis, oxidative stress, and inflammation. Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. We have designed and synthesized novel chalcone derivatives as Nrf2 activators. The potency of these compounds was measured by the expression of Nrf2 dependent antioxidant genes GCLM, NQO1, and… CONTINUE READING
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