Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGFR siRNA delivery for triple negative Breast cancer therapy.

@article{Jing2016NovelCP,
  title={Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGFR siRNA delivery for triple negative Breast cancer therapy.},
  author={Hui Jing and Wen Cheng and Shouqiang Li and Bolin Wu and Xiaoping Leng and Shouping Xu and Jiawei Tian},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2016},
  volume={146},
  pages={387-95}
}
The lack of safe and effective gene delivery strategies remains a bottleneck for cancer gene therapy. Here, we describe the synthesis, characterization, and application of cell-penetrating peptide (CPP)-loaded nanobubbles (NBs), which are characterized by their safety, strong penetrating power and high gene loading capability for gene delivery. An epidermal growth factor receptor (EGFR)-targeted small interfering RNA (siEGFR) was transfected into triple negative breast cancer (TNBC) cells via… CONTINUE READING

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