Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo

@article{Chien2005NovelCC,
  title={Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo},
  author={P Chien and Jinkang Wang and Danielle Carbonaro and Sabrina Lei and Bruce M Miller and Saifuddin Sheikh and Shoukath M. Ali and Moghis U. Ahmad and Imran Ahmad},
  journal={Cancer Gene Therapy},
  year={2005},
  volume={12},
  pages={321-328}
}
Cationic liposomes have been successfully used as an alternative approach to viral systems to deliver nucleic acids. However, high toxicity and inconsistent transfection efficiency have been associated with the currently available liposomes. Therefore, a novel cationic liposome was developed based on a synthetic cationic cardiolipin analogue (CCLA) to test the DNA transfection efficiency. This CCLA-based liposome was also used to determine the therapeutic efficacy of c-raf small interfering RNA… CONTINUE READING
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Synthesis of novel cationic cardiolipin analogues for the optimal delivery of therapeutic agents

  • K Kasireddy, MU Ahmad, SM Ali, I. Ahmad
  • Tetrahedron Lett
  • 2004
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