Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery.

  title={Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery.},
  author={Zanna Hyv{\"o}nen and Aiva Plotniece and I Reine and B Chekavichus and Gunars Duburs and Arto Urtti},
  journal={Biochimica et biophysica acta},
  volume={1509 1-2},
In order to find new efficient and safe agents for gene delivery, we have designed and synthesized nine novel single- and double-charged amphiphiles on the base of 1,4-dihydropyridine (1,4-DHP) ring. Some biophysical properties of the amphiphilic dihydropyridines and their complexes with DNA were examined. We investigated the transfer of beta-galactosidase gene into fibroblasts (CV1-P) and retinal pigment epithelial (D 4O7) cell lines in vitro. The structure-property relationships of the… CONTINUE READING


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