Novel catanionic surfactant vesicle vaccines protect against Francisella tularensis LVS and confer significant partial protection against F. tularensis Schu S4 strain.

@article{Richard2014NovelCS,
  title={Novel catanionic surfactant vesicle vaccines protect against Francisella tularensis LVS and confer significant partial protection against F. tularensis Schu S4 strain.},
  author={Katharina Richard and Barbara J. Mann and Lenea Stocker and Eileen M Barry and Aiping Qin and Leah E. Cole and Matthew T. Hurley and Robert K Ernst and Suzanne M. Michalek and D. C. Stein and Philip DeShong and Stefanie N Vogel},
  journal={Clinical and vaccine immunology : CVI},
  year={2014},
  volume={21 2},
  pages={
          212-26
        }
}
Francisella tularensis is a Gram-negative immune-evasive coccobacillus that causes tularemia in humans and animals. A safe and efficacious vaccine that is protective against multiple F. tularensis strains has yet to be developed. In this study, we tested a novel vaccine approach using artificial pathogens, synthetic nanoparticles made from catanionic surfactant vesicles that are functionalized by the incorporation of either F. tularensis type B live vaccine strain (F. tularensis LVS [LVS-V]) or… CONTINUE READING

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