Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells.

@article{Verma2004NovelCE,
  title={Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells.},
  author={Subodh Verma and Vivek Rao and Richard D. Weisel and Shu-hong Li and Paul W. M. Fedak and Santiago Gabriel Miriuka and R. K.-Y. Li},
  journal={The Journal of surgical research},
  year={2004},
  volume={119 1},
  pages={66-71}
}
Cardioprotective strategies are needed to prevent perioperative myocardial dysfunction in high-risk patients undergoing cardiac surgery. Despite accumulating evidence that statins exert lipid-independent cardioprotective effects, these have been ascribed primarily to improvements in endothelial function and neutrophil-endothelial interaction. The direct effects of statins on cardiomyocytes (independent of endothelial cells) remain unknown. Using a well-characterized model of low-volume hypoxia… CONTINUE READING

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