Novel capsaicin analogues as potential anticancer agents: synthesis, biological evaluation, and in silico approach.

Abstract

A novel class of benzo[d][1,3]dioxol-5-ylmethyl alkyl/aryl amide and ester analogues of capsaicin were designed, synthesized, and evaluated for their cytotoxic activity against human and murine cancer cell lines (B16F10, SK-MEL-28, NCI-H1299, NCI-H460, SK-BR-3, and MDA-MB-231) and human lung fibroblasts (MRC-5). Three compounds (5f, 6c, and 6e) selectively… (More)
DOI: 10.1002/ardp.201400233

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Cite this paper

@article{Damio2014NovelCA, title={Novel capsaicin analogues as potential anticancer agents: synthesis, biological evaluation, and in silico approach.}, author={Mariana Celestina Frojuello Costa Bernstorff Dami{\~a}o and Kerly F. M. Pasqualoto and Adilson Kleber Ferreira and Sarah Fernandes Teixeira and Ricardo Antunes Azevedo and Jose A. M. Barbuto and Fanny Palace-Berl and Gilberto C Franchi-Junior and Alexandre Eduardo Nowill and Maur{\'i}cio Temotheo Tavares and Roberto Parise-Filho}, journal={Archiv der Pharmazie}, year={2014}, volume={347 12}, pages={885-95} }