Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases.


Several reports indicate that melatonin is involved in the regulation of bone metabolism. To examine the direct effect of melatonin on osteoclasts and osteoblasts, we developed an in vitro assay using fish scales that contain osteoclasts, osteoblasts, and bone matrix, all of which are similar to those found in mammalian membrane bone. Using the assay, we… (More)
DOI: 10.1111/j.1600-079X.2008.00623.x


2 Figures and Tables