Novel biologically-inspired rosette nanotube PLLA scaffolds for improving human mesenchymal stem cell chondrogenic differentiation.

@article{Childs2013NovelBR,
  title={Novel biologically-inspired rosette nanotube PLLA scaffolds for improving human mesenchymal stem cell chondrogenic differentiation.},
  author={Allie Childs and Usha D. Hemraz and Nathan J. Castro and Hicham Fenniri and Lijie Grace Zhang},
  journal={Biomedical materials},
  year={2013},
  volume={8 6},
  pages={065003}
}
Cartilage defects are a persistent issue in orthopedic tissue engineering where acute and chronic tissue damage stemming from osteoarthritis, trauma, and sport injuries, present a common and serious clinical problem. Unlike bone, cartilage repair continues to be largely intractable due to the tissue's inherently poor regenerative capacity. Thus, the objective of this study is to design a novel tissue engineered nanostructured cartilage scaffold via biologically-inspired self-assembling rosette… CONTINUE READING
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