Novel biological functions of interleukin-4: formation of tube-like structures by vascular endothelial cells in vitro and angiogenesis in vivo.

@article{Fukushi1998NovelBF,
  title={Novel biological functions of interleukin-4: formation of tube-like structures by vascular endothelial cells in vitro and angiogenesis in vivo.},
  author={Jun-ichi Fukushi and Takayuki Morisaki and Tadahisa Shono and Akihiko Nishie and Hitoe Torisu and Mayumi Ono and Michihiko Kuwano},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={250 2},
  pages={444-8}
}
The effect of interleukin-4 (IL-4) on angiogenesis was studied in vitro and in vivo. Human recombinant IL-4 significantly stimulated the formation of tube-like structures in collagen gels by bovine aortic endothelial cells as well as by human microvascular endothelial cells. Human recombinant IL-4 at 50-500 U/ml stimulated by about two- to threefold the formation of tubes by bovine aortic endothelial cells; the rate was comparable to that of basic fibroblast growth factor. Tube formation was… CONTINUE READING
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