Corpus ID: 202000211

Novel binding pattern of chlorotoxin (TM-601) in glioma cells in vitro.

@article{Wiranowska2006NovelBP,
  title={Novel binding pattern of chlorotoxin (TM-601) in glioma cells in vitro.},
  author={M. Wiranowska and G. Etienne and S. Ladd and V. Alvarez},
  journal={Cancer Research},
  year={2006},
  volume={66},
  pages={1290-1290}
}
5488 These studies are focused on evaluating the cellular target(s) and cellular effects of chlorotoxin (also called TM-601), a scorpion-derived, 36-amino acid peptide with specificity to tumor cells including glioma. TM-601 is a new experimental drug currently in Phase II clinical trials for treatment of adult recurrent glioma. Here we used the biotinylated version of TM-601, called TM-602, to evaluate binding to human U373 MG and mouse G-26 glioma cells. The glioma cell cultures were seeded… Expand