Novel binding partners of Ldb1 are required for haematopoietic development.

  title={Novel binding partners of Ldb1 are required for haematopoietic development.},
  author={Natalia T. Meier and Sanja Krpic and Patrick Rodriguez and John Strouboulis and Maria Alice Monti and Jeroen Krijgsveld and Martin Gering and Roger Patient and Arnd Hostert and Frank Grosveld},
  volume={133 24},
Ldb1, a ubiquitously expressed LIM domain binding protein, is essential in a number of tissues during development. It interacts with Gata1, Tal1, E2A and Lmo2 to form a transcription factor complex regulating late erythroid genes. We identify a number of novel Ldb1 interacting proteins in erythroleukaemic cells, in particular the repressor protein Eto-2 (and its family member Mtgr1), the cyclin-dependent kinase Cdk9, and the bridging factor Lmo4. MO-mediated knockdowns in zebrafish show these… CONTINUE READING


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