Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase.


Toward developing antileishmanial agents with mode of action targeted to DNA topoisomerases of Leishmania donovani, we have synthesized a large number of derivatives of betulin. The compound, a natural triterpene isolated from the cork layer of Betula spp. plants exhibits several pharmacological properties. Three compounds (disuccinyl betulin, diglutaryl… (More)
DOI: 10.1124/mol.111.072785


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