Novel avermectins produced by mutational biosynthesis.

  title={Novel avermectins produced by mutational biosynthesis.},
  author={Christopher J Dutton and Scott Gibson and andrew. goudie and Kelvin S. Holdom and Michael Pacey and John C. Ruddock and J. D. Bu'lock and Michael K. Richards},
  journal={The Journal of antibiotics},
  volume={44 3},
Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity. 
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